7P11

Galectin-8 N-terminal carbohydrate recognition domain in complex with quinoline D-galactal ligand

7P11 の概要

• エントリーDOI: 10.2210/pdb7p11/pdb
• 分子名称: Isoform 2 of Galectin-8, Galectin-8, 2-[[(2~{R},3~{R},4~{R})-2-(hydroxymethyl)-3-oxidanyl-3,4-dihydro-2~{H}-pyran-4-yl]oxymethyl]quinoline-7-carboxylic acid, ... (5 entities in total)
• 機能のキーワード: inhibitor, complex, galectin, lectin, d-galactal, sugar binding protein
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 34747.13

構造登録者

Hassan, M.,Hakansson, M.,Nilsson, J.U.,Kovacic, R. (登録日: 2021-07-01, 公開日: 2021-12-15, 最終更新日: 2024-01-31)

• 主引用文献: Hassan, M.,Baussiere, F.,Guzelj, S.,Sundin, A.P.,Hakansson, M.,Kovacic, R.,Leffler, H.,Tomasic, T.,Anderluh, M.,Jakopin, Z.,Nilsson, U.J.; Structure-Guided Design of d-Galactal Derivatives with High Affinity and Selectivity for the Galectin-8 N-Terminal Domain.; Acs Med.Chem.Lett., 12:1745-1752, 2021; PubMed: 34795863; DOI: 10.1021/acsmedchemlett.1c00371

実験手法

X-RAY DIFFRACTION (2.1 Å)