7P0O
mitoNEET bound to M1 molecule
Summary for 7P0O
Entry DOI | 10.2210/pdb7p0o/pdb |
Descriptor | CDGSH iron-sulfur domain-containing protein 1, FE2/S2 (INORGANIC) CLUSTER, 2-benzamido-4-[(2~{R})-1,2,3,4-tetrahydronaphthalen-2-yl]thiophene-3-carboxylic acid, ... (5 entities in total) |
Functional Keywords | [2fe-2s] proteins, neet proteins, destabilizer, m1, metal binding protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 19003.21 |
Authors | Livnah, O.,Eisenberg-Domovich, Y.,Marjault, H.B.,Nechushtai, R. (deposition date: 2021-06-30, release date: 2022-05-25, Last modification date: 2024-01-31) |
Primary citation | Marjault, H.B.,Karmi, O.,Zuo, K.,Michaeli, D.,Eisenberg-Domovich, Y.,Rossetti, G.,de Chassey, B.,Vonderscher, J.,Cabantchik, I.,Carloni, P.,Mittler, R.,Livnah, O.,Meldrum, E.,Nechushtai, R. An anti-diabetic drug targets NEET (CISD) proteins through destabilization of their [2Fe-2S] clusters. Commun Biol, 5:437-437, 2022 Cited by PubMed: 35538231DOI: 10.1038/s42003-022-03393-x PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.65 Å) |
Structure validation
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