7OY4

VDR complex of a side-chain hydroxylated derivatives of lithocholic acid

7OY4 の概要

• エントリーDOI: 10.2210/pdb7oy4/pdb
• 分子名称: Vitamin D3 receptor A, Nuclear receptor coactivator 1, (3S,6R)-6-[(3R,5R,8R,9S,10S,13R,14S,17R)-10,13-dimethyl-3-(2-methyl-2-oxidanyl-propyl)-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]heptane-1,3-diol, ... (4 entities in total)
• 機能のキーワード: nuclear recptor, agonist, transcription
• 由来する生物種: Danio rerio (Zebrafish); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 36299.49

構造登録者

Rochel, N. (登録日: 2021-06-23, 公開日: 2021-09-01, 最終更新日: 2024-01-31)

• 主引用文献: Gonzalez, C.M.,Gaikwad, S.,Lasanta, G.,Loureiro, J.,Nilsson, N.,Peluso-Iltis, C.,Rochel, N.,Mourino, A.; Design, synthesis and evaluation of side-chain hydroxylated derivatives of lithocholic acid as potent agonists of the vitamin D receptor (VDR).; Bioorg.Chem., 115:105202-105202, 2021; PubMed: 34339974; DOI: 10.1016/j.bioorg.2021.105202

実験手法

X-RAY DIFFRACTION (2 Å)