7OVI

Protein kinase MKK7 in complex with phenethyltriazole-substituted pyrazolopyrimidine

7OVI の概要

• エントリーDOI: 10.2210/pdb7ovi/pdb
• 分子名称: Dual specificity mitogen-activated protein kinase kinase 7, 1-[(3~{R})-3-[4-azanyl-3-[1-(2-phenylethyl)-1,2,3-triazol-4-yl]pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]propan-1-one (3 entities in total)
• 機能のキーワード: inhibitor, complex, mkk7, kinase, triazole, click-chemistry, cuacc, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 36592.38

構造登録者

Kleinboelting, S.,Buehrmann, M.,Mueller, M.P.,Rauh, D. (登録日: 2021-06-15, 公開日: 2022-07-20, 最終更新日: 2024-01-31)

• 主引用文献: Gehrtz, P.,Marom, S.,Buhrmann, M.,Hardick, J.,Kleinbolting, S.,Shraga, A.,Dubiella, C.,Gabizon, R.,Wiese, J.N.,Muller, M.P.,Cohen, G.,Babaev, I.,Shurrush, K.,Avram, L.,Resnick, E.,Barr, H.,Rauh, D.,London, N.; Optimization of Covalent MKK7 Inhibitors via Crude Nanomole-Scale Libraries.; J.Med.Chem., 65:10341-10356, 2022; PubMed: 35912476; DOI: 10.1021/acs.jmedchem.1c02206

実験手法

X-RAY DIFFRACTION (1.95 Å)