7OUM

BDM88855 inhibitor bound to the transmembrane domain of AcrB-R971A

Summary for 7OUM

Entry DOI	10.2210/pdb7oum/pdb
Descriptor	Multidrug efflux pump subunit AcrB, SULFATE ION, N-OCTANE, ... (13 entities in total)
Functional Keywords	multidrug efflux pump, membrane protein, transport protein
Biological source	Escherichia coli More
Total number of polymer chains	5
Total formula weight	388259.67
Authors	Tam, H.K.,Foong, W.E.,Pos, K.M. (deposition date: 2021-06-12, release date: 2021-12-29, Last modification date: 2024-01-31)
Primary citation	Ple, C.,Tam, H.K.,Vieira Da Cruz, A.,Compagne, N.,Jimenez-Castellanos, J.C.,Muller, R.T.,Pradel, E.,Foong, W.E.,Malloci, G.,Ballee, A.,Kirchner, M.A.,Moshfegh, P.,Herledan, A.,Herrmann, A.,Deprez, B.,Willand, N.,Vargiu, A.V.,Pos, K.M.,Flipo, M.,Hartkoorn, R.C. Pyridylpiperazine-based allosteric inhibitors of RND-type multidrug efflux pumps. Nat Commun, 13:115-115, 2022 Cited by PubMed: 35013254 DOI: 10.1038/s41467-021-27726-2 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.45 Å)

Structure validation