7OTY

DNA-PKcs in complex with M3814

Summary for 7OTY

Entry DOI	10.2210/pdb7oty/pdb
EMDB information	13069
Descriptor	DNA-dependent protein kinase catalytic subunit,DNA-PKcs, (~{S})-[2-chloranyl-4-fluoranyl-5-(7-morpholin-4-ylquinazolin-4-yl)phenyl]-(6-methoxypyridazin-3-yl)methanol (2 entities in total)
Functional Keywords	complex, inhibitor, dna repair, dna binding protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	1
Total formula weight	471857.31
Authors	Liang, S.,Thomas, S.E.,Blundell, T.L. (deposition date: 2021-06-10, release date: 2022-01-12, Last modification date: 2022-10-05)
Primary citation	Liang, S.,Thomas, S.E.,Chaplin, A.K.,Hardwick, S.W.,Chirgadze, D.Y.,Blundell, T.L. Structural insights into inhibitor regulation of the DNA repair protein DNA-PKcs. Nature, 601:643-648, 2022 Cited by PubMed: 34987222 DOI: 10.1038/s41586-021-04274-9 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.96 Å)

Structure validation