7OPS

Crystal structure of haspin in complex with ZW282 (compound 2a)

7OPS の概要

• エントリーDOI: 10.2210/pdb7ops/pdb
• 分子名称: Serine/threonine-protein kinase haspin, 2-methylsulfanyl-10-nitro-pyrido[3,4-g]quinazoline, GLYCEROL, ... (4 entities in total)
• 機能のキーワード: haspin, kinase inhibitor, gsg2, structural genomics, structural genomics consortium, sgc, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 41075.86

構造登録者

Chaikuad, A.,Anizon, F.,Knapp, S.,Structural Genomics Consortium (SGC) (登録日: 2021-06-01, 公開日: 2021-07-21, 最終更新日: 2024-01-31)

• 主引用文献: Zeinyeh, W.,Esvan, Y.J.,Josselin, B.,Defois, M.,Baratte, B.,Knapp, S.,Chaikuad, A.,Anizon, F.,Giraud, F.,Ruchaud, S.,Moreau, P.; Synthesis and biological evaluation of Haspin inhibitors: Kinase inhibitory potency and cellular activity.; Eur.J.Med.Chem., 236:114369-114369, 2022; PubMed: 35447555; DOI: 10.1016/j.ejmech.2022.114369

実験手法