7OPJ
Trypanosoma brucei PTR1 (TbPTR1) in complex with pyrimethamine
Summary for 7OPJ
Entry DOI | 10.2210/pdb7opj/pdb |
Descriptor | Pteridine reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 5-(4-CHLORO-PHENYL)-6-ETHYL-PYRIMIDINE-2,4-DIAMINE, ... (6 entities in total) |
Functional Keywords | trypanosoma brucei, ptr1, tbptr1, pyrimethamine, oxidoreductase |
Biological source | Trypanosoma brucei brucei |
Total number of polymer chains | 4 |
Total formula weight | 126975.90 |
Authors | Tassone, G.,Landi, G.,Pozzi, C.,Mangani, S. (deposition date: 2021-05-31, release date: 2021-07-14, Last modification date: 2024-01-31) |
Primary citation | Tassone, G.,Landi, G.,Linciano, P.,Francesconi, V.,Tonelli, M.,Tagliazucchi, L.,Costi, M.P.,Mangani, S.,Pozzi, C. Evidence of Pyrimethamine and Cycloguanil Analogues as Dual Inhibitors of Trypanosoma brucei Pteridine Reductase and Dihydrofolate Reductase. Pharmaceuticals, 14:-, 2021 Cited by PubMed: 34209148DOI: 10.3390/ph14070636 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.34 Å) |
Structure validation
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