7OPJ

Trypanosoma brucei PTR1 (TbPTR1) in complex with pyrimethamine

Summary for 7OPJ

Entry DOI	10.2210/pdb7opj/pdb
Descriptor	Pteridine reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 5-(4-CHLORO-PHENYL)-6-ETHYL-PYRIMIDINE-2,4-DIAMINE, ... (6 entities in total)
Functional Keywords	trypanosoma brucei, ptr1, tbptr1, pyrimethamine, oxidoreductase
Biological source	Trypanosoma brucei brucei
Total number of polymer chains	4
Total formula weight	126975.90
Authors	Tassone, G.,Landi, G.,Pozzi, C.,Mangani, S. (deposition date: 2021-05-31, release date: 2021-07-14, Last modification date: 2024-01-31)
Primary citation	Tassone, G.,Landi, G.,Linciano, P.,Francesconi, V.,Tonelli, M.,Tagliazucchi, L.,Costi, M.P.,Mangani, S.,Pozzi, C. Evidence of Pyrimethamine and Cycloguanil Analogues as Dual Inhibitors of Trypanosoma brucei Pteridine Reductase and Dihydrofolate Reductase. Pharmaceuticals, 14:-, 2021 Cited by PubMed: 34209148 DOI: 10.3390/ph14070636 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.34 Å)

Structure validation