7ONV

Carbonic anhydrase II mutant (I91C) dually binding an IrCp* complex to generate an artificial transfer hydrogenase (ATHase)

Summary for 7ONV

• Entry DOI: 10.2210/pdb7onv/pdb
• Descriptor: Carbonic anhydrase 2, ZINC ION, 4-[2-(4-azanyl-9-chloranyl-2',3',4',5',6'-pentamethyl-7-oxidanylidene-spiro[1$l^{4},8-diaza-9$l^{8}-iridabicyclo[4.3.0]nona-1,3,5-triene-9,1'-1$l^{8}-iridapentacyclo[2.2.0.0^{1,3}.0^{1,5}.0^{2,6}]hexane]-8-yl)ethyl]benzenesulfonamide, ... (5 entities in total)
• Functional Keywords: artificial metalloenzyme, artificial transfer hydrogenase, metal binding protein, oxidoreductase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 30729.50

Authors

Stein, A.,Dongping, C.,Cotelle, Y.,Rebelein, J.G.,Ward, T.R. (deposition date: 2021-05-26, release date: 2021-12-01, Last modification date: 2024-02-07)

• Primary citation: Stein, A.,Chen, D.,Igareta, N.V.,Cotelle, Y.,Rebelein, J.G.,Ward, T.R.; A Dual Anchoring Strategy for the Directed Evolution of Improved Artificial Transfer Hydrogenases Based on Carbonic Anhydrase.; Acs Cent.Sci., 7:1874-1884, 2021; PubMed: 34849402; DOI: 10.1021/acscentsci.1c00825

Experimental method

X-RAY DIFFRACTION (1.04 Å)