7OLV
MerTK kinase domain with type 1.5 inhibitor containing a di-methyl, cyano pyrazole group
7OLV の概要
エントリーDOI | 10.2210/pdb7olv/pdb |
関連するPDBエントリー | 7OLS |
分子名称 | Tyrosine-protein kinase Mer, 4-[4-[5-[imidazo[1,2-a]pyridin-6-ylmethyl(methyl)amino]-1,3,4-oxadiazol-2-yl]-3-methyl-phenyl]-2,5-dimethyl-pyrazole-3-carbonitrile, CHLORIDE ION, ... (5 entities in total) |
機能のキーワード | tyrosine kinase inhibitor, structure-based drug design, type 1.5 inhibitor, transferase |
由来する生物種 | Homo sapiens (Human) |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 35040.18 |
構造登録者 | Pflug, A.,Schimpl, M.,McCoull, W.,Nissink, J.W.M.,Winter-Holt, J. (登録日: 2021-05-20, 公開日: 2021-09-15, 最終更新日: 2024-01-31) |
主引用文献 | McCoull, W.,Boyd, S.,Brown, M.R.,Coen, M.,Collingwood, O.,Davies, N.L.,Doherty, A.,Fairley, G.,Goldberg, K.,Hardaker, E.,He, G.,Hennessy, E.J.,Hopcroft, P.,Hodgson, G.,Jackson, A.,Jiang, X.,Karmokar, A.,Laine, A.L.,Lindsay, N.,Mao, Y.,Markandu, R.,McMurray, L.,McLean, N.,Mooney, L.,Musgrove, H.,Nissink, J.W.M.,Pflug, A.,Reddy, V.P.,Rawlins, P.B.,Rivers, E.,Schimpl, M.,Smith, G.F.,Tentarelli, S.,Travers, J.,Troup, R.I.,Walton, J.,Wang, C.,Wilkinson, S.,Williamson, B.,Winter-Holt, J.,Yang, D.,Zheng, Y.,Zhu, Q.,Smith, P.D. Optimization of an Imidazo[1,2- a ]pyridine Series to Afford Highly Selective Type I1/2 Dual Mer/Axl Kinase Inhibitors with In Vivo Efficacy. J.Med.Chem., 64:13524-13539, 2021 Cited by PubMed: 34478292DOI: 10.1021/acs.jmedchem.1c00920 主引用文献が同じPDBエントリー |
実験手法 |
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