7OKI
Crystal structure of human BCL6 BTB domain in complex with compound 12b
Summary for 7OKI
Entry DOI | 10.2210/pdb7oki/pdb |
Descriptor | B-cell lymphoma 6 protein, ALA-TRP-VAL-ILE-PRO-ALA, (2R)-2-[[6-[(2-chloranyl-3-cyano-pyridin-4-yl)amino]-2-oxidanylidene-1H-quinolin-4-yl]amino]-N-methyl-propanamide, ... (6 entities in total) |
Functional Keywords | cancer, lymphoma, inhibitor, transcription |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 15932.00 |
Authors | Collie, G.W.,Le Bihan, Y.-V.,van Montfort, R.L.M. (deposition date: 2021-05-17, release date: 2021-12-08, Last modification date: 2024-01-31) |
Primary citation | Lloyd, M.G.,Huckvale, R.,Cheung, K.J.,Rodrigues, M.J.,Collie, G.W.,Pierrat, O.A.,Gatti Iou, M.,Carter, M.,Davis, O.A.,McAndrew, P.C.,Gunnell, E.,Le Bihan, Y.V.,Talbot, R.,Henley, A.T.,Johnson, L.D.,Hayes, A.,Bright, M.D.,Raynaud, F.I.,Meniconi, M.,Burke, R.,van Montfort, R.L.M.,Rossanese, O.W.,Bellenie, B.R.,Hoelder, S. Into Deep Water: Optimizing BCL6 Inhibitors by Growing into a Solvated Pocket. J.Med.Chem., 64:17079-17097, 2021 Cited by PubMed: 34846884DOI: 10.1021/acs.jmedchem.1c00946 PDB entries with the same primary citation |
Experimental method |
Structure validation
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