7OED

Crystal structure of the human METTL3-METTL14 complex with compound UOZ019a

Summary for 7OED

Entry DOI	10.2210/pdb7oed/pdb
Descriptor	N6-adenosine-methyltransferase catalytic subunit, N6-adenosine-methyltransferase non-catalytic subunit, 4-[(4,4-dimethylpiperidin-1-yl)methyl]-~{N}-[[(3~{R})-1-[6-(methylamino)pyrimidin-4-yl]-3-oxidanyl-piperidin-3-yl]methyl]-2-oxidanyl-benzamide, ... (5 entities in total)
Functional Keywords	mettl3, inhibitor, complex, transferase
Biological source	Homo sapiens (Human) More
Total number of polymer chains	2
Total formula weight	62306.99
Authors	Bedi, R.K.,Huang, D.,Caflisch, A. (deposition date: 2021-05-03, release date: 2021-10-20, Last modification date: 2024-10-09)
Primary citation	Bedi, R.K.,Huang, D.,Li, Y.,Caflisch, A. Structure-Based Design of Inhibitors of the m6A-RNA Writer Enzyme METTL3 Acs Bio Med Chem Au, 2023 Cited by DOI: 10.1021/acsbiomedchemau.3c00023 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation