7ODV

Plant peptide hormone receptor complex H1LS1

これはPDB形式変換不可エントリーです。

7ODV の概要

• エントリーDOI: 10.2210/pdb7odv/pdb
• 分子名称: Receptor-like protein kinase HSL1, Somatic embryogenesis receptor kinase 1, Protein IDA, ... (10 entities in total)
• 機能のキーワード: plant receptor lrr pepide hormone, peptide binding protein complex, peptide binding protein
• 由来する生物種: Arabidopsis thaliana (Mouse-ear cress); 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 189876.67

構造登録者

Roman, A.O.,Jimenez-Sandoval, P.,Santiago, J. (登録日: 2021-04-30, 公開日: 2022-02-16, 最終更新日: 2024-01-31)

主引用文献

Roman, A.O.,Jimenez-Sandoval, P.,Augustin, S.,Broyart, C.,Hothorn, L.A.,Santiago, J.
HSL1 and BAM1/2 impact epidermal cell development by sensing distinct signaling peptides.
Nat Commun, 13:876-876, 2022

PubMed Abstract: The membrane receptor kinases HAESA and HSL2 recognize a family of IDA/IDL signaling peptides to control cell separation processes in different plant organs. The homologous HSL1 has been reported to regulate epidermal cell patterning by interacting with a different class of signaling peptides from the CLE family. Here we demonstrate that HSL1 binds IDA/IDL peptides with high, and CLE peptides with lower affinity, respectively. Ligand sensing capability and receptor activation of HSL1 require a SERK co-receptor kinase. Crystal structures with IDA/IDLs or with CLE9 reveal that HSL1-SERK1 complex recognizes the entire IDA/IDL signaling peptide, while only parts of CLE9 are bound to the receptor. In contrast, the receptor kinase BAM1 interacts with the entire CLE9 peptide with high affinity and specificity. Furthermore, the receptor tandem BAM1/BAM2 regulates epidermal cell division homeostasis. Consequently, HSL1-IDLs and BAM1/BAM2-CLEs independently regulate cell patterning in the leaf epidermal tissue.

PubMed: 35169143
DOI: 10.1038/s41467-022-28558-4

実験手法

X-RAY DIFFRACTION (2.31 Å)