7OC4

Alpha-humulene synthase AsR6 from Sarocladium schorii in complex with thiolodiphosphate and a cyclized reaction product.

Summary for 7OC4

• Entry DOI: 10.2210/pdb7oc4/pdb
• Descriptor: Alpha-humulene synthase AsR6, ZINC ION, TRIHYDROGEN THIODIPHOSPHATE, ... (8 entities in total)
• Functional Keywords: cyclase, terpene cyclase, 2e-humulene, alpha-humulene, humulene, xenovulene, tropolone sesquiterpenoid, biosynthetic protein
• Biological source: Sarocladium schorii (Acremonium strictum (strain IMI 501407))
• Total number of polymer chains: 2
• Total formula weight: 98500.90

Authors

Schotte, C.,Lukat, P.,Deuschmann, A.,Blankenfeldt, W.,Cox, R.J. (deposition date: 2021-04-26, release date: 2021-07-07, Last modification date: 2024-05-01)

• Primary citation: Schotte, C.,Lukat, P.,Deuschmann, A.,Blankenfeldt, W.,Cox, R.J.; Understanding and Engineering the Stereoselectivity of Humulene Synthase.; Angew.Chem.Int.Ed.Engl., 60:20308-20312, 2021; PubMed: 34180566; DOI: 10.1002/anie.202106718

Experimental method

X-RAY DIFFRACTION (2.03 Å)