7O7K

Crystal structure of the human DYRK1A kinase domain bound to abemaciclib

7O7K の概要

• エントリーDOI: 10.2210/pdb7o7k/pdb
• 分子名称: Dual specificity tyrosine-phosphorylation-regulated kinase 1A, CITRATE ANION, N-{5-[(4-ethylpiperazin-1-yl)methyl]pyridin-2-yl}-5-fluoro-4-[4-fluoro-2-methyl-1-(propan-2-yl)-1H-benzimidazol-6-yl]py rimidin-2-amine, ... (7 entities in total)
• 機能のキーワード: serine/threonine kinase, cmgc kinase, dual specificity tyrosine-phosphorylation-regulated kinase 1a, dyrk1a, transcription, abemaciclib, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 87294.02

構造登録者

Kaltheuner, I.H.,Anand, K.,Geyer, M. (登録日: 2021-04-13, 公開日: 2021-11-24, 最終更新日: 2024-10-09)

• 主引用文献: Kaltheuner, I.H.,Anand, K.,Moecking, J.,Duster, R.,Wang, J.,Gray, N.S.,Geyer, M.; Abemaciclib is a potent inhibitor of DYRK1A and HIP kinases involved in transcriptional regulation.; Nat Commun, 12:6607-6607, 2021; PubMed: 34785661; DOI: 10.1038/s41467-021-26935-z

実験手法

X-RAY DIFFRACTION (1.82 Å)