7O5N

Crystal Structure of a Class D carbapenemase complexed with Avibactam

This is a non-PDB format compatible entry.

Summary for 7O5N

• Entry DOI: 10.2210/pdb7o5n/pdb
• Descriptor: Beta-lactamase, 1-BUTANOL, (2S,5R)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carboxamide, ... (6 entities in total)
• Functional Keywords: oxa, avibactam, chloride, hydrolase
• Biological source: Klebsiella pneumoniae
• Total number of polymer chains: 4
• Total formula weight: 122844.07

Authors

Zhou, Q.,Zhang, Z.,He, Y.,Jin, Y. (deposition date: 2021-04-09, release date: 2022-04-20, Last modification date: 2024-03-06)

• Primary citation: Zhou, Q.,Catalan, P.,Bell, H.,Baumann, P.,Cooke, R.,Evans, R.,Yang, J.,Zhang, Z.,Zappala, D.,Zhang, Y.,Blackburn, G.M.,He, Y.,Jin, Y.; An Ion-Pair Induced Intermediate Complex Captured in Class D Carbapenemase Reveals Chloride Ion as a Janus Effector Modulating Activity; Acs Cent.Sci., 2023; DOI: 10.1021/acscentsci.3c00609

Experimental method

X-RAY DIFFRACTION (1.6 Å)