7O09

Crystal structure of the human METTL3-METTL14 complex bound to Compound 7 (ADO_AC_074)

7O09 の概要

• エントリーDOI: 10.2210/pdb7o09/pdb
• 分子名称: N6-adenosine-methyltransferase catalytic subunit, N6-adenosine-methyltransferase non-catalytic subunit, 6-[4-[6-[(4,4-dimethylpiperidin-1-yl)methyl]pyridin-3-yl]-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl]-N-(phenylmethyl)pyrimidin-4-amine, ... (5 entities in total)
• 機能のキーワード: mettl3, inhibitor, complex, transferase
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 62366.10

構造登録者

Bedi, R.K.,Dolbois, A.,Caflisch, A. (登録日: 2021-03-25, 公開日: 2021-09-01, 最終更新日: 2024-01-31)

• 主引用文献: Dolbois, A.,Bedi, R.K.,Bochenkova, E.,Muller, A.,Moroz-Omori, E.V.,Huang, D.,Caflisch, A.; 1,4,9-Triazaspiro[5.5]undecan-2-one Derivatives as Potent and Selective METTL3 Inhibitors.; J.Med.Chem., 64:12738-12760, 2021; PubMed: 34431664; DOI: 10.1021/acs.jmedchem.1c00773

実験手法

X-RAY DIFFRACTION (1.8 Å)