7NWY

Crystal structure of alpha carbonic anhydrase from schistosoma mansoni with 4-(3-(4-fluorophenyl)ureido)benzenesulfonamide

This is a non-PDB format compatible entry.

Summary for 7NWY

• Entry DOI: 10.2210/pdb7nwy/pdb
• Descriptor: Carbonic anhydrase, ZINC ION, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
• Functional Keywords: schistosoma mansoni, carbonic anhydrase, metalloenzyme, inhibitor, neglected diseases, sulfonamide, lyase
• Biological source: Schistosoma mansoni (Blood fluke)
• Total number of polymer chains: 2
• Total formula weight: 73357.39

Authors

Angeli, A.,Ferraroni, M. (deposition date: 2021-03-17, release date: 2022-03-30, Last modification date: 2024-01-31)

• Primary citation: Angeli, A.,Ferraroni, M.,Da'dara, A.A.,Selleri, S.,Pinteala, M.,Carta, F.,Skelly, P.J.,Supuran, C.T.; Structural Insights into Schistosoma mansoni Carbonic Anhydrase (SmCA) Inhibition by Selenoureido-Substituted Benzenesulfonamides.; J.Med.Chem., 64:10418-10428, 2021; PubMed: 34232641; DOI: 10.1021/acs.jmedchem.1c00840

Experimental method

X-RAY DIFFRACTION (1.807 Å)