7NRQ

Paired helical filament from primary age-related tauopathy brain

Summary for 7NRQ

• Entry DOI: 10.2210/pdb7nrq/pdb
• EMDB information: 12549
• Descriptor: Microtubule-associated protein tau (1 entity in total)
• Functional Keywords: tau filament, protein fibril
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 10
• Total formula weight: 459198.71

Authors

Shi, Y.,Murzin, A.G.,Falcon, B.,Epstein, A.,Machin, J.,Tempest, P.,Newell, K.L.,Vidal, R.,Garringer, H.J.,Sahara, N.,Higuchi, M.,Ghetti, B.,Jang, M.,Scheres, S.H.W.,Goedert, M. (deposition date: 2021-03-04, release date: 2021-03-24, Last modification date: 2021-04-28)

• Primary citation: Shi, Y.,Murzin, A.G.,Falcon, B.,Epstein, A.,Machin, J.,Tempest, P.,Newell, K.L.,Vidal, R.,Garringer, H.J.,Sahara, N.,Higuchi, M.,Ghetti, B.,Jang, M.K.,Scheres, S.H.W.,Goedert, M.; Cryo-EM structures of tau filaments from Alzheimer's disease with PET ligand APN-1607.; Acta Neuropathol, 141:697-708, 2021; PubMed: 33723967; DOI: 10.1007/s00401-021-02294-3

Experimental method

ELECTRON MICROSCOPY (2.76 Å)