7NQB

X.ray structure of the oxaliplatin/beta-lactoglobulin adduct

これはPDB形式変換不可エントリーです。

7NQB の概要

• エントリーDOI: 10.2210/pdb7nqb/pdb
• 分子名称: Beta-lactoglobulin, PLATINUM (II) ION (3 entities in total)
• 機能のキーワード: beta-lactoglobulin, oxaliplatin, metal-based drugs, drug delivery, protein-metalation, transport protein
• 由来する生物種: Bos taurus (Bovine)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 36797.43

構造登録者

Merlino, A.,Loreto, D.,Ferraro, G. (登録日: 2021-03-01, 公開日: 2022-03-23, 最終更新日: 2024-11-20)

主引用文献

Monti, D.M.,Loreto, D.,Iacobucci, I.,Ferraro, G.,Pratesi, A.,D'Elia, L.,Monti, M.,Merlino, A.
Protein-Based Delivery Systems for Anticancer Metallodrugs: Structure and Biological Activity of the Oxaliplatin/ beta-Lactoglobulin Adduct.
Pharmaceuticals, 15:-, 2022

PubMed Abstract: β-lactoglobulin is the major component of whey. Here, the adduct formed upon the reaction of the protein with oxaliplatin (OXA) has been prepared, structurally characterized by X-ray crystallography and electrospray ionization-mass spectrometry, and evaluated as a cytotoxic agent. The data demonstrate that OXA rapidly binds β-lactoglobulin via coordination with a Met7 side chain upon release of the oxalate ligand. The adduct is significantly more cytotoxic than the free drug and induces apoptosis in cancer cells. Overall, our results suggest that metallodrug/β-lactoglobulin adducts can be used as anticancer agents and that the protein can be used as a metallodrug delivery system.

PubMed: 35455422
DOI: 10.3390/ph15040425

実験手法

X-RAY DIFFRACTION (2.01 Å)