7NP6

ROR(gamma)t ligand binding domain in complex with allosteric ligand FM257

7NP6 の概要

• エントリーDOI: 10.2210/pdb7np6/pdb
• 分子名称: Nuclear receptor ROR-gamma, 4-[[3-[2-chloranyl-6-(trifluoromethyl)phenyl]-5-(1~{H}-pyrazol-4-yl)-1,2-oxazol-4-yl]methoxy]benzoic acid (3 entities in total)
• 機能のキーワード: nuclear receptor, retinoic acid receptor-related orphan receptor gamma t, inverse agonist, nuclear protein
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 29220.09

構造登録者

Oerlemans, G.J.M.,Somsen, B.A.,de Vries, R.M.J.M.,Meijer, F.A.,Brunsveld, L. (登録日: 2021-02-26, 公開日: 2021-06-02, 最終更新日: 2024-01-31)

• 主引用文献: Meijer, F.A.,Saris, A.O.W.M.,Doveston, R.G.,Oerlemans, G.J.M.,de Vries, R.M.J.M.,Somsen, B.A.,Unger, A.,Klebl, B.,Ottmann, C.,Cossar, P.J.,Brunsveld, L.; Structure-Activity Relationship Studies of Trisubstituted Isoxazoles as Selective Allosteric Ligands for the Retinoic-Acid-Receptor-Related Orphan Receptor gamma t.; J.Med.Chem., 64:9238-9258, 2021; PubMed: 34008974; DOI: 10.1021/acs.jmedchem.1c00475

実験手法

X-RAY DIFFRACTION (1.84 Å)