7NMQ

Bacillus cereus HblL1 toxin component

7NMQ の概要

• エントリーDOI: 10.2210/pdb7nmq/pdb
• 分子名称: Hemolysin BL lytic component L1, DI(HYDROXYETHYL)ETHER, 1,2-ETHANEDIOL, ... (4 entities in total)
• 機能のキーワード: bacillus cereus, toxin, haemolysin bl, alpha helical pore forming toxin
• 由来する生物種: Bacillus cereus
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 39974.08

構造登録者

Rizkallah, P.J.,Berry, C. (登録日: 2021-02-23, 公開日: 2021-04-07, 最終更新日: 2024-01-31)

主引用文献

Worthy, H.L.,Williamson, L.J.,Auhim, H.S.,Leppla, S.H.,Sastalla, I.,Jones, D.D.,Rizkallah, P.J.,Berry, C.
The Crystal Structure of Bacillus cereus HblL 1 .
Toxins, 13:-, 2021

PubMed Abstract: The Hbl toxin is a three-component haemolytic complex produced by strains and implicated as a cause of diarrhoea in food poisoning. While the structure of the HblB component of this toxin is known, the structures of the other components are unresolved. Here, we describe the expression of the recombinant HblL component and the elucidation of its structure to 1.36 Å. Like HblB, it is a member of the alpha-helical pore-forming toxin family. In comparison to other members of this group, it has an extended hydrophobic beta tongue region that may be involved in pore formation. Molecular docking was used to predict possible interactions between HblL and HblB, and suggests a head to tail dimer might form, burying the HblL beta tongue region.

PubMed: 33807365
DOI: 10.3390/toxins13040253

実験手法

X-RAY DIFFRACTION (1.36 Å)