7NL5

Structure of the catalytic domain of the Bacillus circulans alpha-1,6 Mannanase in complex with an alpha-1,6-alpha-manno-cyclophellitol trisaccharide inhibitor

Summary for 7NL5

Entry DOI	10.2210/pdb7nl5/pdb
Descriptor	Alpha-1,6-mannanase, alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose, (1R,6S)-5beta-(Hydroxymethyl)-7-oxabicyclo[4.1.0]heptane-2beta,3beta,4alpha-triol, ... (5 entities in total)
Functional Keywords	mannanase, cyclophellitol, epoxide, hydrolase
Biological source	Bacillus circulans
Total number of polymer chains	1
Total formula weight	41627.51
Authors	Schroeder, S.,Offen, W.A.,Males, A.,Jin, Y.,De Boer, C.,Enotarpi, J.,Marino, L.,van der Marel, G.A.,Florea, B.I.,Codee, J.D.C.,Overkleeft, H.S.,Davies, G.J. (deposition date: 2021-02-22, release date: 2021-04-28, Last modification date: 2024-01-31)
Primary citation	Schroder, S.P.,Offen, W.A.,Males, A.,Jin, Y.,de Boer, C.,Enotarpi, J.,Marino, L.,van der Marel, G.A.,Florea, B.I.,Codee, J.D.C.,Overkleeft, H.S.,Davies, G.J. Development of Non-Hydrolysable Oligosaccharide Activity-Based Inactivators for Endoglycanases: A Case Study on alpha-1,6 Mannanases. Chemistry, 27:9519-9523, 2021 Cited by PubMed: 33878235 DOI: 10.1002/chem.202101255 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.4 Å)

Structure validation