7NI3
CRYSTAL STRUCTURE OF NATIVE HUMAN MYELOPEROXIDASE IN COMPLEX WITH CPD 3
Summary for 7NI3
Entry DOI | 10.2210/pdb7ni3/pdb |
Related | 7NI1 |
Descriptor | Myeloperoxidase, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, PROTOPORPHYRIN IX CONTAINING FE, ... (10 entities in total) |
Functional Keywords | oxidoreductase, complex, inhibitor |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 4 |
Total formula weight | 135122.71 |
Authors | Sjogren, T.,Inghardt, T. (deposition date: 2021-02-11, release date: 2022-02-23, Last modification date: 2024-01-31) |
Primary citation | Inghardt, T.,Antonsson, T.,Ericsson, C.,Hovdal, D.,Johannesson, P.,Johansson, C.,Jurva, U.,Kajanus, J.,Kull, B.,Michaelsson, E.,Pettersen, A.,Sjogren, T.,Sorensen, H.,Westerlund, K.,Lindstedt, E.L. Discovery of AZD4831, a Mechanism-Based Irreversible Inhibitor of Myeloperoxidase, As a Potential Treatment for Heart Failure with Preserved Ejection Fraction. J.Med.Chem., 65:11485-11496, 2022 Cited by PubMed: 36005476DOI: 10.1021/acs.jmedchem.1c02141 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
Download full validation report