7NI1

CRYSTAL STRUCTURE OF NATIVE HUMAN MYELOPEROXIDASE IN COMPLEX WITH CPD 9

7NI1 の概要

• エントリーDOI: 10.2210/pdb7ni1/pdb
• 分子名称: Myeloperoxidase, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ... (10 entities in total)
• 機能のキーワード: oxidoreductase, complex, inhibitor
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 135738.21

構造登録者

Sjogren, T.,Inghardt, T. (登録日: 2021-02-11, 公開日: 2022-02-23, 最終更新日: 2024-01-31)

• 主引用文献: Inghardt, T.,Antonsson, T.,Ericsson, C.,Hovdal, D.,Johannesson, P.,Johansson, C.,Jurva, U.,Kajanus, J.,Kull, B.,Michaelsson, E.,Pettersen, A.,Sjogren, T.,Sorensen, H.,Westerlund, K.,Lindstedt, E.L.; Discovery of AZD4831, a Mechanism-Based Irreversible Inhibitor of Myeloperoxidase, As a Potential Treatment for Heart Failure with Preserved Ejection Fraction.; J.Med.Chem., 65:11485-11496, 2022; PubMed: 36005476; DOI: 10.1021/acs.jmedchem.1c02141

実験手法

X-RAY DIFFRACTION (2.11 Å)