7NH4

Co-Crystal Structure of Akt1 in Complex with Covalent-Allosteric Akt Inhibitor 3

7NH4 の概要

• エントリーDOI: 10.2210/pdb7nh4/pdb
• 分子名称: RAC-alpha serine/threonine-protein kinase, ~{N}-[3-[1-[[4-[5-(hydroxymethyl)-3-phenyl-pyridin-2-yl]phenyl]methyl]piperidin-4-yl]-2-oxidanylidene-1~{H}-benzimidazol-5-yl]propanamide, ACETATE ION, ... (4 entities in total)
• 機能のキーワード: akt1, akt2, akt3, covalent-allosteric, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 52425.80

構造登録者

Landel, I.,Mueller, M.P.,Rauh, D. (登録日: 2021-02-10, 公開日: 2021-09-08, 最終更新日: 2024-01-31)

• 主引用文献: Quambusch, L.,Depta, L.,Landel, I.,Lubeck, M.,Kirschner, T.,Nabert, J.,Uhlenbrock, N.,Weisner, J.,Kostka, M.,Levy, L.M.,Schultz-Fademrecht, C.,Glanemann, F.,Althoff, K.,Muller, M.P.,Siveke, J.T.,Rauh, D.; Cellular model system to dissect the isoform-selectivity of Akt inhibitors.; Nat Commun, 12:5297-5297, 2021; PubMed: 34489430; DOI: 10.1038/s41467-021-25512-8

実験手法

X-RAY DIFFRACTION (2.3 Å)