7NG1

Crystal structure of alpha Carbonic anhydrase from Schistoso ma mansoni bound to 1-(4-iodophenyl)-3-[2-(4-sulfamoylphenyl)ethyl]selenourea

7NG1 の概要

• エントリーDOI: 10.2210/pdb7ng1/pdb
• 分子名称: Carbonic anhydrase, ~{N}'-(4-iodophenyl)-~{N}-[2-(4-sulfamoylphenyl)ethyl]carbamimidoselenoic acid, ZINC ION, ... (6 entities in total)
• 機能のキーワード: lyase
• 由来する生物種: Schistosoma mansoni (Blood fluke)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 77987.25

構造登録者

Ferraroni, M.,Angeli, A.,Supuran, C.T. (登録日: 2021-02-08, 公開日: 2022-03-02, 最終更新日: 2024-01-31)

• 主引用文献: Angeli, A.,Ferraroni, M.,Da'dara, A.A.,Selleri, S.,Pinteala, M.,Carta, F.,Skelly, P.J.,Supuran, C.T.; Structural Insights into Schistosoma mansoni Carbonic Anhydrase (SmCA) Inhibition by Selenoureido-Substituted Benzenesulfonamides.; J.Med.Chem., 64:10418-10428, 2021; PubMed: 34232641; DOI: 10.1021/acs.jmedchem.1c00840

実験手法

X-RAY DIFFRACTION (1.67 Å)