7NC6

Glutathione-S-transferase GliG in complex with cyclo[L-Phe-L-Ser]-bis-glutathione-adduct

Summary for 7NC6

• Entry DOI: 10.2210/pdb7nc6/pdb
• Related: 7NC3 7NC5
• Descriptor: Glutathione S-transferase GliG, (2~{S})-2-azanyl-5-[[(2~{R})-3-[(2~{R},5~{R})-5-(hydroxymethyl)-3,6-bis(oxidanylidene)-2-(phenylmethyl)-5-sulfanyl-piperazin-2-yl]sulfanyl-1-(2-hydroxy-2-oxoethylamino)-1-oxidanylidene-propan-2-yl]amino]-5-oxidanylidene-pentanoic acid, 1,2-ETHANEDIOL, ... (5 entities in total)
• Functional Keywords: aspergillus fumigatus, mycotoxin, glutathione-s-transferase, carbon-sulphur-bond, epidithiodioxopiperazine, biosynthetic protein
• Biological source: Aspergillus fumigatus A1163
• Total number of polymer chains: 6
• Total formula weight: 177453.08

Authors

Groll, M.,Huber, E.M. (deposition date: 2021-01-28, release date: 2021-05-12, Last modification date: 2024-01-31)

• Primary citation: Scherlach, K.,Kuttenlochner, W.,Scharf, D.H.,Brakhage, A.A.,Hertweck, C.,Groll, M.,Huber, E.M.; Structural and Mechanistic Insights into C-S Bond Formation in Gliotoxin.; Angew.Chem.Int.Ed.Engl., 60:14188-14194, 2021; PubMed: 33909314; DOI: 10.1002/anie.202104372

Experimental method

X-RAY DIFFRACTION (2.1 Å)