7NBQ

Co-crystal structure of Human Nicotinamide N-methyltransferase (NNMT) with the tricyclic inhibitor (4)

Summary for 7NBQ

Entry DOI	10.2210/pdb7nbq/pdb
Related	7BKG 7BLE 7NJB 7NMB
Descriptor	Nicotinamide N-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE, 2-methyl-1,2,6,7-tetrahydro-3H,5H-pyrido[3,2,1-ij]quinazolin-3-imine, ... (4 entities in total)
Functional Keywords	methyl transferase, drug discovery, inhibitor complex, nicotinamide, metabolic disorders, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	4
Total formula weight	128206.85
Authors	Schreuder, H.A.,Liesum, A. (deposition date: 2021-01-27, release date: 2021-03-17, Last modification date: 2024-01-31)
Primary citation	Kannt, A.,Rajagopal, S.,Hallur, M.S.,Swamy, I.,Kristam, R.,Dhakshinamoorthy, S.,Czech, J.,Zech, G.,Schreuder, H.,Ruf, S. Novel Inhibitors of Nicotinamide- N -Methyltransferase for the Treatment of Metabolic Disorders. Molecules, 26:-, 2021 Cited by PubMed: 33668468 DOI: 10.3390/molecules26040991 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.479 Å)

Structure validation