7NBQ

Co-crystal structure of Human Nicotinamide N-methyltransferase (NNMT) with the tricyclic inhibitor (4)

7NBQ の概要

• エントリーDOI: 10.2210/pdb7nbq/pdb
• 関連するPDBエントリー: 7BKG 7BLE 7NJB 7NMB
• 分子名称: Nicotinamide N-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE, 2-methyl-1,2,6,7-tetrahydro-3H,5H-pyrido[3,2,1-ij]quinazolin-3-imine, ... (4 entities in total)
• 機能のキーワード: methyl transferase, drug discovery, inhibitor complex, nicotinamide, metabolic disorders, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 128206.85

構造登録者

Schreuder, H.A.,Liesum, A. (登録日: 2021-01-27, 公開日: 2021-03-17, 最終更新日: 2024-01-31)

• 主引用文献: Kannt, A.,Rajagopal, S.,Hallur, M.S.,Swamy, I.,Kristam, R.,Dhakshinamoorthy, S.,Czech, J.,Zech, G.,Schreuder, H.,Ruf, S.; Novel Inhibitors of Nicotinamide- N -Methyltransferase for the Treatment of Metabolic Disorders.; Molecules, 26:-, 2021; PubMed: 33668468; DOI: 10.3390/molecules26040991

実験手法

X-RAY DIFFRACTION (2.479 Å)