7NBJ

Co-crystal structure of Human Nicotinamide N-methyltransferase (NNMT) with the bisubstrate-like inhibitor (1)

7NBJ の概要

• エントリーDOI: 10.2210/pdb7nbj/pdb
• 関連するPDBエントリー: 7BKG 7BLE
• 分子名称: Nicotinamide N-methyltransferase, 2-hydroxy-1-(4-(isoquinolin-5-yl)piperazin-1-yl)-2-methyl-3-(3-methyl-4-phenyl-1H-pyrazol-1-yl)propan-1-one, GLYCEROL, ... (4 entities in total)
• 機能のキーワード: methyl transferase, drug discovery, inhibitor complex, nicotinamide, metabolic disorders, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 127778.43

構造登録者

Schreuder, H.A.,Liesum, A. (登録日: 2021-01-27, 公開日: 2021-03-17, 最終更新日: 2024-01-31)

• 主引用文献: Kannt, A.,Rajagopal, S.,Hallur, M.S.,Swamy, I.,Kristam, R.,Dhakshinamoorthy, S.,Czech, J.,Zech, G.,Schreuder, H.,Ruf, S.; Novel Inhibitors of Nicotinamide- N -Methyltransferase for the Treatment of Metabolic Disorders.; Molecules, 26:-, 2021; PubMed: 33668468; DOI: 10.3390/molecules26040991

実験手法

X-RAY DIFFRACTION (2.275 Å)