7NAH

Crystal structure of the TIR domain from human SARM1 in complex with 2AD

7NAH の概要

• エントリーDOI: 10.2210/pdb7nah/pdb
• 分子名称: Sterile alpha and TIR motif-containing protein 1, [[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{S},4~{R},5~{R})-3,4-bis(oxidanyl)-5-(8-oxidanylidene-7~{H}-2,7-naphthyridin-2-yl)oxolan-2-yl]methyl hydrogen phosphate (3 entities in total)
• 機能のキーワード: nadase, axon degeneration, hydrolase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 34044.31

構造登録者

Shi, Y.,Ve, T. (登録日: 2021-06-21, 公開日: 2022-03-23, 最終更新日: 2023-10-18)

• 主引用文献: Shi, Y.,Kerry, P.S.,Nanson, J.D.,Bosanac, T.,Sasaki, Y.,Krauss, R.,Saikot, F.K.,Adams, S.E.,Mosaiab, T.,Masic, V.,Mao, X.,Rose, F.,Vasquez, E.,Furrer, M.,Cunnea, K.,Brearley, A.,Gu, W.,Luo, Z.,Brillault, L.,Landsberg, M.J.,DiAntonio, A.,Kobe, B.,Milbrandt, J.,Hughes, R.O.,Ve, T.; Structural basis of SARM1 activation, substrate recognition, and inhibition by small molecules.; Mol.Cell, 82:1643-, 2022; PubMed: 35334231; DOI: 10.1016/j.molcel.2022.03.007

実験手法

X-RAY DIFFRACTION (1.79 Å)