7N8T
Crystal Structure of AMP-bound Human JNK2
Summary for 7N8T
Entry DOI | 10.2210/pdb7n8t/pdb |
Descriptor | Mitogen-activated protein kinase 9, ADENOSINE MONOPHOSPHATE, HEXAETHYLENE GLYCOL, ... (4 entities in total) |
Functional Keywords | jnk2, mitogen-activated protein kinase 9, transferase, amp |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 41505.72 |
Authors | Li, L.,Gurbani, D.,Westover, K.D. (deposition date: 2021-06-15, release date: 2022-06-22, Last modification date: 2023-10-25) |
Primary citation | Lu, W.,Liu, Y.,Gao, Y.,Geng, Q.,Gurbani, D.,Li, L.,Ficarro, S.B.,Meyer, C.J.,Sinha, D.,You, I.,Tse, J.,He, Z.,Ji, W.,Che, J.,Kim, A.Y.,Yu, T.,Wen, K.,Anderson, K.C.,Marto, J.A.,Westover, K.D.,Zhang, T.,Gray, N.S. Development of a Covalent Inhibitor of c-Jun N-Terminal Protein Kinase (JNK) 2/3 with Selectivity over JNK1. J.Med.Chem., 66:3356-3371, 2023 Cited by PubMed: 36826833DOI: 10.1021/acs.jmedchem.2c01834 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.69 Å) |
Structure validation
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