7N8T

Crystal Structure of AMP-bound Human JNK2

Summary for 7N8T

Entry DOI	10.2210/pdb7n8t/pdb
Descriptor	Mitogen-activated protein kinase 9, ADENOSINE MONOPHOSPHATE, HEXAETHYLENE GLYCOL, ... (4 entities in total)
Functional Keywords	jnk2, mitogen-activated protein kinase 9, transferase, amp
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	41505.72
Authors	Li, L.,Gurbani, D.,Westover, K.D. (deposition date: 2021-06-15, release date: 2022-06-22, Last modification date: 2023-10-25)
Primary citation	Lu, W.,Liu, Y.,Gao, Y.,Geng, Q.,Gurbani, D.,Li, L.,Ficarro, S.B.,Meyer, C.J.,Sinha, D.,You, I.,Tse, J.,He, Z.,Ji, W.,Che, J.,Kim, A.Y.,Yu, T.,Wen, K.,Anderson, K.C.,Marto, J.A.,Westover, K.D.,Zhang, T.,Gray, N.S. Development of a Covalent Inhibitor of c-Jun N-Terminal Protein Kinase (JNK) 2/3 with Selectivity over JNK1. J.Med.Chem., 66:3356-3371, 2023 Cited by PubMed: 36826833 DOI: 10.1021/acs.jmedchem.2c01834 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.69 Å)

Structure validation