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7N8F

The crystal structure of I38T mutant PA endonuclease (2009/H1N1/CALIFORNIA) in complex with SJ000988288

Summary for 7N8F
Entry DOI10.2210/pdb7n8f/pdb
DescriptorPolymerase acidic protein, MANGANESE (II) ION, Hexa Vinylpyrrolidone K15, ... (6 entities in total)
Functional Keywordsnuclease, influenza, inhibitor resistance, viral protein-inhibitor complex, hydrolase, viral protein/inhibitor
Biological sourceInfluenza A virus (strain swl A/California/04/2009 H1N1)
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Total number of polymer chains1
Total formula weight24588.66
Authors
Cuypers, M.G.,Slavish, J.P.,Rankovic, Z.,White, S.W. (deposition date: 2021-06-14, release date: 2022-06-15, Last modification date: 2023-12-27)
Primary citationSlavish, P.J.,Cuypers, M.G.,Rimmer, M.A.,Abdolvahabi, A.,Jeevan, T.,Kumar, G.,Jarusiewicz, J.A.,Vaithiyalingam, S.,Jones, J.C.,Bowling, J.J.,Price, J.E.,DuBois, R.M.,Min, J.,Webby, R.J.,Rankovic, Z.,White, S.W.
Chemical scaffold recycling: Structure-guided conversion of an HIV integrase inhibitor into a potent influenza virus RNA-dependent RNA polymerase inhibitor designed to minimize resistance potential.
Eur.J.Med.Chem., 247:115035-115035, 2023
Cited by
PubMed: 36603507
DOI: 10.1016/j.ejmech.2022.115035
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.35 Å)
Structure validation

221051

건을2024-06-12부터공개중

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