Loading
PDBj
メニューPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

7N8F

The crystal structure of I38T mutant PA endonuclease (2009/H1N1/CALIFORNIA) in complex with SJ000988288

7N8F の概要
エントリーDOI10.2210/pdb7n8f/pdb
分子名称Polymerase acidic protein, MANGANESE (II) ION, Hexa Vinylpyrrolidone K15, ... (6 entities in total)
機能のキーワードnuclease, influenza, inhibitor resistance, viral protein-inhibitor complex, hydrolase, viral protein/inhibitor
由来する生物種Influenza A virus (strain swl A/California/04/2009 H1N1)
詳細
タンパク質・核酸の鎖数1
化学式量合計24588.66
構造登録者
Cuypers, M.G.,Slavish, J.P.,Rankovic, Z.,White, S.W. (登録日: 2021-06-14, 公開日: 2022-06-15, 最終更新日: 2023-12-27)
主引用文献Slavish, P.J.,Cuypers, M.G.,Rimmer, M.A.,Abdolvahabi, A.,Jeevan, T.,Kumar, G.,Jarusiewicz, J.A.,Vaithiyalingam, S.,Jones, J.C.,Bowling, J.J.,Price, J.E.,DuBois, R.M.,Min, J.,Webby, R.J.,Rankovic, Z.,White, S.W.
Chemical scaffold recycling: Structure-guided conversion of an HIV integrase inhibitor into a potent influenza virus RNA-dependent RNA polymerase inhibitor designed to minimize resistance potential.
Eur.J.Med.Chem., 247:115035-115035, 2023
Cited by
PubMed: 36603507
DOI: 10.1016/j.ejmech.2022.115035
主引用文献が同じPDBエントリー
実験手法
X-RAY DIFFRACTION (2.35 Å)
構造検証レポート
Validation report summary of 7n8f
検証レポート(詳細版)ダウンロードをダウンロード

221051

件を2024-06-12に公開中

PDB statisticsPDBj update infoContact PDBjnumon