7N4M

Crystal structure of SARS-CoV-2 receptor binding domain in complex with neutralizing human antibody WRAIR-2151.

7N4M の概要

• エントリーDOI: 10.2210/pdb7n4m/pdb
• 分子名称: WRAIR-2151 antibody Fab heavy chain, Spike protein S1, WRAIR-2151 antibody Fab light chain, ... (4 entities in total)
• 機能のキーワード: neutralizing antibody, sars-cov-2, wrair-2151, receptor binding domain, antiviral protein, viral protein-immune system complex, viral protein/immune system
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 70723.46

構造登録者

Sankhala, R.S.,Joyce, M.G. (登録日: 2021-06-04, 公開日: 2021-11-10, 最終更新日: 2023-10-18)

• 主引用文献: Dussupt, V.,Sankhala, R.S.,Mendez-Rivera, L.,Townsley, S.M.,Schmidt, F.,Wieczorek, L.,Lal, K.G.,Donofrio, G.C.,Tran, U.,Jackson, N.D.,Zaky, W.I.,Zemil, M.,Tritsch, S.R.,Chen, W.H.,Martinez, E.J.,Ahmed, A.,Choe, M.,Chang, W.C.,Hajduczki, A.,Jian, N.,Peterson, C.E.,Rees, P.A.,Rutkowska, M.,Slike, B.M.,Selverian, C.N.,Swafford, I.,Teng, I.T.,Thomas, P.V.,Zhou, T.,Smith, C.J.,Currier, J.R.,Kwong, P.D.,Rolland, M.,Davidson, E.,Doranz, B.J.,Mores, C.N.,Hatziioannou, T.,Reiley, W.W.,Bieniasz, P.D.,Paquin-Proulx, D.,Gromowski, G.D.,Polonis, V.R.,Michael, N.L.,Modjarrad, K.,Joyce, M.G.,Krebs, S.J.; Low-dose in vivo protection and neutralization across SARS-CoV-2 variants by monoclonal antibody combinations.; Nat.Immunol., 22:1503-1514, 2021; PubMed: 34716452; DOI: 10.1038/s41590-021-01068-z

実験手法

X-RAY DIFFRACTION (3.79 Å)