7N3H

Crystal structure of an anti-SARS-CoV-2 human neutralizing antibody Fab fragment C099

7N3H の概要

• エントリーDOI: 10.2210/pdb7n3h/pdb
• 分子名称: C099 Fab Heavy Chain, C099 Fab Light Chain (3 entities in total)
• 機能のキーワード: severe acute respiratory syndrome coronavirus-2, spike protein, neutralizing antibodies, immune system
• 由来する生物種: Homo sapiens; 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 47702.18

構造登録者

Flyak, A.I.,Bjorkman, P.J.,Barnes, C.O. (登録日: 2021-06-01, 公開日: 2021-08-04, 最終更新日: 2023-10-18)

• 主引用文献: Muecksch, F.,Weisblum, Y.,Barnes, C.O.,Schmidt, F.,Schaefer-Babajew, D.,Wang, Z.,C Lorenzi, J.C.,Flyak, A.I.,DeLaitsch, A.T.,Huey-Tubman, K.E.,Hou, S.,Schiffer, C.A.,Gaebler, C.,Da Silva, J.,Poston, D.,Finkin, S.,Cho, A.,Cipolla, M.,Oliveira, T.Y.,Millard, K.G.,Ramos, V.,Gazumyan, A.,Rutkowska, M.,Caskey, M.,Nussenzweig, M.C.,Bjorkman, P.J.,Hatziioannou, T.,Bieniasz, P.D.; Affinity maturation of SARS-CoV-2 neutralizing antibodies confers potency, breadth, and resilience to viral escape mutations.; Immunity, 54:1853-, 2021; PubMed: 34331873; DOI: 10.1016/j.immuni.2021.07.008

実験手法

X-RAY DIFFRACTION (1.26 Å)