7N3F

Crystal structure of an anti-SARS-CoV-2 human neutralizing antibody Fab fragment C080

Summary for 7N3F

• Entry DOI: 10.2210/pdb7n3f/pdb
• Descriptor: C080 Fab Heavy Chain, C080 Fab Light Chain (3 entities in total)
• Functional Keywords: severe acute respiratory syndrome coronavirus-2, spike protein, neutralizing antibodies, immune system
• Biological source: Homo sapiens; More
• Total number of polymer chains: 2
• Total formula weight: 47848.30

Authors

Flyak, A.I.,Bjorkman, P.J.,Barnes, C.O. (deposition date: 2021-06-01, release date: 2021-08-04, Last modification date: 2023-10-18)

• Primary citation: Muecksch, F.,Weisblum, Y.,Barnes, C.O.,Schmidt, F.,Schaefer-Babajew, D.,Wang, Z.,C Lorenzi, J.C.,Flyak, A.I.,DeLaitsch, A.T.,Huey-Tubman, K.E.,Hou, S.,Schiffer, C.A.,Gaebler, C.,Da Silva, J.,Poston, D.,Finkin, S.,Cho, A.,Cipolla, M.,Oliveira, T.Y.,Millard, K.G.,Ramos, V.,Gazumyan, A.,Rutkowska, M.,Caskey, M.,Nussenzweig, M.C.,Bjorkman, P.J.,Hatziioannou, T.,Bieniasz, P.D.; Affinity maturation of SARS-CoV-2 neutralizing antibodies confers potency, breadth, and resilience to viral escape mutations.; Immunity, 54:1853-, 2021; PubMed: 34331873; DOI: 10.1016/j.immuni.2021.07.008

Experimental method

X-RAY DIFFRACTION (1.9 Å)