7N1C

SARS-CoV-2 RLQ peptide-specific TCR pRLQ3

7N1C の概要

• エントリーDOI: 10.2210/pdb7n1c/pdb
• 分子名称: pRLQ3 T cell receptor alpha chain, pRLQ3 T cell receptor beta chain (3 entities in total)
• 機能のキーワード: tcr, sars-cov-2, spike, immune system
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 50246.22

構造登録者

Wu, D.,Mariuzza, R.A. (登録日: 2021-05-27, 公開日: 2021-07-28, 最終更新日: 2024-10-30)

主引用文献

Wu, D.,Kolesnikov, A.,Yin, R.,Guest, J.D.,Gowthaman, R.,Shmelev, A.,Serdyuk, Y.,Dianov, D.V.,Efimov, G.A.,Pierce, B.G.,Mariuzza, R.A.
Structural assessment of HLA-A2-restricted SARS-CoV-2 spike epitopes recognized by public and private T-cell receptors.
Nat Commun, 13:19-19, 2022

PubMed Abstract: T cells play a vital role in combatting SARS-CoV-2 and forming long-term memory responses. Whereas extensive structural information is available on neutralizing antibodies against SARS-CoV-2, such information on SARS-CoV-2-specific T-cell receptors (TCRs) bound to their peptide-MHC targets is lacking. Here we determine the structures of a public and a private TCR from COVID-19 convalescent patients in complex with HLA-A2 and two SARS-CoV-2 spike protein epitopes (YLQ and RLQ). The structures reveal the basis for selection of particular TRAV and TRBV germline genes by the public but not the private TCR, and for the ability of the TCRs to recognize natural variants of RLQ but not YLQ. Neither TCR recognizes homologous epitopes from human seasonal coronaviruses. By elucidating the mechanism for TCR recognition of an immunodominant yet variable epitope (YLQ) and a conserved but less commonly targeted epitope (RLQ), this study can inform prospective efforts to design vaccines to elicit pan-coronavirus immunity.

PubMed: 35013235
DOI: 10.1038/s41467-021-27669-8

実験手法

X-RAY DIFFRACTION (1.881 Å)