7N14
Crystal structure of 4-(1H-1,2,4-triazol-1-yl)benzoic acid-bound CYP199A4
Summary for 7N14
Entry DOI | 10.2210/pdb7n14/pdb |
Descriptor | Cytochrome P450, 4-(1H-1,2,4-triazol-1-yl)benzoic acid, PROTOPORPHYRIN IX CONTAINING FE, ... (5 entities in total) |
Functional Keywords | cytochrome p450, inhibitor, triazole, oxidoreductase-inhibitor complex, oxidoreductase/inhibitor |
Biological source | Rhodopseudomonas palustris (strain HaA2) |
Total number of polymer chains | 1 |
Total formula weight | 45428.54 |
Authors | Podgorski, M.N.,Bruning, J.B.,Bell, S.G. (deposition date: 2021-05-26, release date: 2022-02-02, Last modification date: 2023-10-18) |
Primary citation | Podgorski, M.N.,Coleman, T.,Giang, P.D.,Wang, C.R.,Bruning, J.B.,Bernhardt, P.V.,De Voss, J.J.,Bell, S.G. To Be, or Not to Be, an Inhibitor: A Comparison of Azole Interactions with and Oxidation by a Cytochrome P450 Enzyme. Inorg.Chem., 61:236-245, 2022 Cited by PubMed: 34910500DOI: 10.1021/acs.inorgchem.1c02786 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.537 Å) |
Structure validation
Download full validation report