7N14

Crystal structure of 4-(1H-1,2,4-triazol-1-yl)benzoic acid-bound CYP199A4

7N14 の概要

• エントリーDOI: 10.2210/pdb7n14/pdb
• 分子名称: Cytochrome P450, 4-(1H-1,2,4-triazol-1-yl)benzoic acid, PROTOPORPHYRIN IX CONTAINING FE, ... (5 entities in total)
• 機能のキーワード: cytochrome p450, inhibitor, triazole, oxidoreductase-inhibitor complex, oxidoreductase/inhibitor
• 由来する生物種: Rhodopseudomonas palustris (strain HaA2)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 45428.54

構造登録者

Podgorski, M.N.,Bruning, J.B.,Bell, S.G. (登録日: 2021-05-26, 公開日: 2022-02-02, 最終更新日: 2023-10-18)

• 主引用文献: Podgorski, M.N.,Coleman, T.,Giang, P.D.,Wang, C.R.,Bruning, J.B.,Bernhardt, P.V.,De Voss, J.J.,Bell, S.G.; To Be, or Not to Be, an Inhibitor: A Comparison of Azole Interactions with and Oxidation by a Cytochrome P450 Enzyme.; Inorg.Chem., 61:236-245, 2022; PubMed: 34910500; DOI: 10.1021/acs.inorgchem.1c02786

実験手法

X-RAY DIFFRACTION (1.537 Å)