7MYC

Structure of proline utilization A with the FAD covalently modified by tetrahydrothiophene

Summary for 7MYC

• Entry DOI: 10.2210/pdb7myc/pdb
• Descriptor: Bifunctional protein PutA, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl (2R,3S,4S)-5-{7,8-dimethyl-2,4-dioxo-5-[(2R)-tetrahydrothiophen-2-yl]-1,3,4,5-tetrahydrobenzo[g]pteridin-10(2H)-yl}-2,3,4-trihydroxypentyl dihydrogen diphosphate (non-preferred name), 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, ... (9 entities in total)
• Functional Keywords: flavoenzyme, rossmann fold, proline dehydrognease, aldehyde dehydrogenase, proline catabolism, substrate channeling, bifunctional enzyme, oxidoreductase
• Biological source: Sinorhizobium meliloti SM11
• Total number of polymer chains: 2
• Total formula weight: 268389.08

Authors

Tanner, J.J.,Campbell, A.C. (deposition date: 2021-05-20, release date: 2021-09-29, Last modification date: 2023-10-18)

• Primary citation: Campbell, A.C.,Prater, A.R.,Bogner, A.N.,Quinn, T.P.,Gates, K.S.,Becker, D.F.,Tanner, J.J.; Photoinduced Covalent Irreversible Inactivation of Proline Dehydrogenase by S-Heterocycles.; Acs Chem.Biol., 16:2268-2279, 2021; PubMed: 34542291; DOI: 10.1021/acschembio.1c00427

Experimental method

X-RAY DIFFRACTION (1.9 Å)