7MYC

Structure of proline utilization A with the FAD covalently modified by tetrahydrothiophene

7MYC の概要

• エントリーDOI: 10.2210/pdb7myc/pdb
• 分子名称: Bifunctional protein PutA, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl (2R,3S,4S)-5-{7,8-dimethyl-2,4-dioxo-5-[(2R)-tetrahydrothiophen-2-yl]-1,3,4,5-tetrahydrobenzo[g]pteridin-10(2H)-yl}-2,3,4-trihydroxypentyl dihydrogen diphosphate (non-preferred name), 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, ... (9 entities in total)
• 機能のキーワード: flavoenzyme, rossmann fold, proline dehydrognease, aldehyde dehydrogenase, proline catabolism, substrate channeling, bifunctional enzyme, oxidoreductase
• 由来する生物種: Sinorhizobium meliloti SM11
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 268389.08

構造登録者

Tanner, J.J.,Campbell, A.C. (登録日: 2021-05-20, 公開日: 2021-09-29, 最終更新日: 2023-10-18)

• 主引用文献: Campbell, A.C.,Prater, A.R.,Bogner, A.N.,Quinn, T.P.,Gates, K.S.,Becker, D.F.,Tanner, J.J.; Photoinduced Covalent Irreversible Inactivation of Proline Dehydrogenase by S-Heterocycles.; Acs Chem.Biol., 16:2268-2279, 2021; PubMed: 34542291; DOI: 10.1021/acschembio.1c00427

実験手法

X-RAY DIFFRACTION (1.9 Å)