7MXA
PRMT5:MEP50 complexed with inhibitor PF-06855800
Summary for 7MXA
Entry DOI | 10.2210/pdb7mxa/pdb |
Descriptor | Protein arginine N-methyltransferase 5, Methylosome protein 50, 7-[(5R)-5-C-(4-chloro-3-fluorophenyl)-beta-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine, ... (4 entities in total) |
Functional Keywords | arginine, methyl, transferase, transferase-transcription complex, transferase/transcription |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 112681.53 |
Authors | McTigue, M.,Deng, Y.L.,Liu, W.,Brooun, A. (deposition date: 2021-05-18, release date: 2021-11-17, Last modification date: 2023-10-18) |
Primary citation | Jensen-Pergakes, K.,Tatlock, J.,Maegley, K.A.,McAlpine, I.J.,McTigue, M.,Xie, T.,Dillon, C.P.,Wang, Y.,Yamazaki, S.,Spiegel, N.,Shi, M.,Nemeth, A.,Miller, N.,Hendrickson, E.,Lam, H.,Sherrill, J.,Chung, C.Y.,McMillan, E.A.,Bryant, S.K.,Palde, P.,Braganza, J.,Brooun, A.,Deng, Y.L.,Goshtasbi, V.,Kephart, S.E.,Kumpf, R.A.,Liu, W.,Patman, R.L.,Rui, E.,Scales, S.,Tran-Dube, M.,Wang, F.,Wythes, M.,Paul, T.A. SAM-Competitive PRMT5 Inhibitor PF-06939999 Demonstrates Antitumor Activity in Splicing Dysregulated NSCLC with Decreased Liability of Drug Resistance. Mol.Cancer Ther., 21:3-15, 2022 Cited by PubMed: 34737197DOI: 10.1158/1535-7163.MCT-21-0620 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.713 Å) |
Structure validation
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