Summary for 7MU6
Entry DOI | 10.2210/pdb7mu6/pdb |
Descriptor | Mitogen-activated protein kinase kinase kinase 5, 2-methoxy-N-(6-{4-[(2S)-1,1,1-trifluoropropan-2-yl]-4H-1,2,4-triazol-3-yl}pyridin-2-yl)pyridine-3-carboxamide (3 entities in total) |
Functional Keywords | ask1, transferase, transferase-inhibitor complex, transferase/inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 75821.58 |
Authors | |
Primary citation | Jones, J.H.,Xin, Z.,Himmelbauer, M.,Dechantsreiter, M.,Enyedy, I.,Hedde, J.,Fang, T.,Coomaraswamy, J.,King, K.W.,Murugan, P.,Santoro, J.C.,Hesson, T.,Walther, D.M.,Wei, R.,Zheng, F.,Marcotte, D.J.,Spilker, K.,Kumar, P.R.,Liu, Y.,Gilfillan, R.,Gonzalez-Lopez de Turiso, F. Discovery of Potent, Selective, and Brain-Penetrant Apoptosis Signal-Regulating Kinase 1 (ASK1) Inhibitors that Modulate Brain Inflammation In Vivo. J.Med.Chem., 64:15402-15419, 2021 Cited by PubMed: 34653340DOI: 10.1021/acs.jmedchem.1c01458 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.165 Å) |
Structure validation
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