7MO9

Cryo-EM map of the c-MET II/HGF I/HGF II (K4 and SPH) sub-complex

Summary for 7MO9

• Entry DOI: 10.2210/pdb7mo9/pdb
• EMDB information: 23919 23920 23921
• Descriptor: Hepatocyte growth factor, Hepatocyte growth factor receptor, 2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose (3 entities in total)
• Functional Keywords: c-met, hgf, receptor tyrosine kinase, signaling protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 3
• Total formula weight: 323970.71

Authors

Uchikawa, E.,Chen, Z.M.,Xiao, G.Y.,Zhang, X.W.,Bai, X.C. (deposition date: 2021-05-01, release date: 2021-06-09, Last modification date: 2021-07-28)

• Primary citation: Uchikawa, E.,Chen, Z.,Xiao, G.Y.,Zhang, X.,Bai, X.C.; Structural basis of the activation of c-MET receptor.; Nat Commun, 12:4074-4074, 2021; PubMed: 34210960; DOI: 10.1038/s41467-021-24367-3

Experimental method

ELECTRON MICROSCOPY (4 Å)