7MND
PTP1B L204A in complex with TCS401
Summary for 7MND
| Entry DOI | 10.2210/pdb7mnd/pdb |
| Descriptor | Tyrosine-protein phosphatase non-receptor type 1, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-(OXALYL-AMINO)-4,5,6,7-TETRAHYDRO-THIENO[2,3-C]PYRIDINE-3-CARBOXYLIC ACID, ... (6 entities in total) |
| Functional Keywords | protein tyrosine phosphatase, hydrolase |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 1 |
| Total formula weight | 36508.53 |
| Authors | Torgeson, K.R.,Page, R.,Peti, W. (deposition date: 2021-04-30, release date: 2022-05-18, Last modification date: 2023-10-18) |
| Primary citation | Torgeson, K.R.,Clarkson, M.W.,Granata, D.,Lindorff-Larsen, K.,Page, R.,Peti, W. Conserved conformational dynamics determine enzyme activity. Sci Adv, 8:eabo5546-eabo5546, 2022 Cited by PubMed: 35921420DOI: 10.1126/sciadv.abo5546 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.29 Å) |
Structure validation
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