7MN7

PTP1B F225Y in complex with TCS401

Summary for 7MN7

• Entry DOI: 10.2210/pdb7mn7/pdb
• Descriptor: Tyrosine-protein phosphatase non-receptor type 1, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, GLYCEROL, ... (6 entities in total)
• Functional Keywords: protein tyrosine phosphatase, hydrolase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 36679.89

Authors

Torgeson, K.R.,Page, R.,Peti, W. (deposition date: 2021-04-30, release date: 2022-05-18, Last modification date: 2023-10-18)

• Primary citation: Torgeson, K.R.,Clarkson, M.W.,Granata, D.,Lindorff-Larsen, K.,Page, R.,Peti, W.; Conserved conformational dynamics determine enzyme activity.; Sci Adv, 8:eabo5546-eabo5546, 2022; PubMed: 35921420; DOI: 10.1126/sciadv.abo5546

Experimental method

X-RAY DIFFRACTION (1.95 Å)